Searching for Rene?

We stumbled across this video on YouTube. It has some terrific graphics and is well worth a look. It also has a spectacularly deep voiced star-trek type talking us through some of the neurochemical processes that occur when tissue is injured or inflamed. It touches on descending modulation, although attributes that to only one brainstem nucleus, and it does not touch on brain processing in any detailed way.  It gets onto substance P and CGRP.

Some of you might recall a quasi game called Searching for Rene, which forces us to carefully monitor what we are saying to people in pain, because they are often searching for any piece of evidence in what we say or how we say it that would support a Rene Descartes-like understanding of pain. Well as flash as this video is, it still commits some faux pas in this way. We found Rene. Can you?